Prana Pets Lignans and Melatonin for Dogs Combo provides you with a natural solution to Cushing’s without the risk of side effects or adverse reactions.
Melatonin for Dogs with Cushing’s - A Powerful & Safe Ally
Without the use of Melatonin, the Lignans are not as effective in treating Cushing's. Melatonin is a natural hormone produced by the pineal gland that helps the body maintain hormonal balance. Properly administered, it’s gentle, effective and carries no risk of side effects. If you’ve studied Cushing’s, you know that it causes the dog’s body to produce excessive amounts of cortisol (a stress hormone). Studies conducted at the University of Tennessee confirmed that melatonin can help reduce excess cortisol levels and for this reason melatonin is an excellent option to help with adrenal issues like Cushing’s.
We have formulated the Lignans and Melatonin for Dogs Combo to have the precise amount of melatonin for maximum safety and therapeutic effect.
Lignans - A Natural Solution for Cushing’s Disease
Flaxseed is one of the world’s oldest cultivated crops, having been grown since the dawn of human civilization. The Latin name of the flaxseed plant is Linum usitatissimum, meaning “very useful.” In addition to food and fiber, flaxseeds also offer medicinal properties to dogs with Cushing’s. Like Melatonin, SDG Lignans extracted from flaxseed have been studied for their ability to help lower excessive cortisol levels. Research shows that combining flaxseed lignans with melatonin serves to lower cortisol levels, rendering this combination particularly useful for dogs with Cushing’s.
Source: STEROID PROFILES IN THE DIAGNOSIS OF CANINE ADRENAL DISORDERS
Jack W. Oliver, DVM, Ph.D Knoxville, TN
Melatonin for Dogs is used in holistic and veterinary medicine along with Lignans as a natural treatment for Cushing's. Studies show reduced cortisol in dogs when given as a combination.
The Melatonin and Lignans Combo can be given with Cushing's Killer Combo.

Directions and Dosage for Lignans and Melatonin for Dogs:
For Dogs less than 25 lbs (10mg Lignans/1mg Melatonin)
1 tablet daily for dogs under 10lbs
2 tablets daily for dogs up to 25lbs
For dogs over 25 lbs (20mg Lignans/3mg Melatonin)
1 tablet daily for dogs under 25-50lbs
2 tablets daily for dogs over 50lbs
Some vets may recommend 1 mg of melatonin every 12 hours for dogs under 10 lbs, or for people who want to give their dog a low dosage of melatonin.
Directions and Dosage for Lignans for Cushing's
Each dosage is one milligram of Lignans per pound of body weight. Up to two milligrams per pound of body weight may be given in one sitting or separated into smaller doses throughout the day.
Ingredients
Active ingredients: SDG Lignans and Melatonin.
Inactive ingredients: Sorbitol, Sucrose, Natural Flavors, Dicalcium Phosphate, Silicon Dioxide, Salt