Adrenal and Lignans Combo


Adrenal and Lignans Combo

Adrenal and Lignans Combo has a rating of 4.6 stars based on 126 reviews.

Research shows lowered cortisol levels in dogs with Cushing's

Helps balance the increased cortisol which contributes to Cushing’s

May help with excessive thirst, increased urination, and excessive panting


Dog under 25lb Dog over 25lb
  • Description
  • Ingredients
  • Directions
  • FAQs
  • Certifications
  • Research

Nature's Remedy

Adrenal Balance is an herbal home remedy formulated to support normal adrenal function in dogs with Cushing’s. Our proprietary blend contains powerful herbs that support normal hormonal balance and help a dog’s body adapt to stress.

Prana Pets Adrenal Balance enhances the balance between the dog’s adrenal glands, pituitary gland, and hypothalamus. Since there is no cure for Cushing’s, treatment has to be long-term, making this holistic option healthier and more beneficial than harsh prescription medications. This natural solution balances a dog’s body rather than simply targeting symptoms and it has no side effects or risks to your pet's health.

Adrenal Balance for Cushing’s is a 100% herbal remedy specifically formulated to provide comprehensive, gentle support to dogs suffering from Cushing’s. Hormonal balance is a delicate and complex issue that must be approached holistically for long-term success. This approach restores balance in the entire HPA (hypothalamic, pituitary, and adrenal) axis.

Your Pet Deserves It

Melatonin is a natural hormone produced by the pineal gland that helps the body maintain hormonal balance. Properly administered, it’s gentle, effective and carries no risk of side effects. Melatonin is a natural calming aid, making it a great addition to your dog's Cushing's regimen. Without the use of melatonin, lignans are not as effective in treating Cushing's on their own.

Flaxseed is one of the world’s oldest cultivated crops, having been grown since the dawn of human civilization. In addition to food and fiber, flaxseeds also offer medicinal properties to dogs with Cushing’s. Like Melatonin, SDG lignans extracted from flaxseed have been studied for their ability to help lower excessive cortisol levels. Research shows that combining flaxseed lignans with melatonin serves to lower cortisol levels*, rendering this combination particularly useful for dogs with Cushing’s.  


Jack W. Oliver, DVM, Ph.D Knoxville, TN 

Melatonin for Dogs is used in holistic and veterinary medicine along with Lignans as a natural treatment for Cushing's. Studies show reduced cortisol in dogs when given as a combination. 


Active Ingredients per drop (0.05 mL): Proprietary blend of Dandelion (root), Burdock (root), Cleavers (herb), Horsetail (herb), Astragalus (root), Ashwagandha (root), Turmeric (root), Panax Ginseng (root)

Inactive Ingredients: Citric Acid, Potassium Sorbate, Purified Water, Vegetable Glycerin USP


For Dogs up to 25 lb:

Active Ingredients per 2 tablets:

SDG Lignans (from Flaxseed Extract)…20 mg

Melatonin…3 mg

Biotin…2 mg

Inactive Ingredients: Cellulose, Dicalcium Phosphate, Natural Flavors (Beef and Vegetables), Silicon Dioxide, Vegetable Stearates.

For Dogs over 25 lb:

Active Ingredients per 2 tablets:

SDG Lignans (from Flaxseed Extract)…80 mg

Melatonin…6 mg

Biotin…3 mg

Inactive Ingredients: Cellulose, Dicalcium Phosphate, Natural Flavors (Beef and Vegetables), Silicon Dioxide, Vegetable Stearates.


Shake well before use. Can be given during or after mealtime or administered orally 3-5 times a day. Use initially for at least one month.


Dogs under 20 lb: 3-5 drops

Dogs 20-50 lb: 6-8 drops

Dogs over 50 lb: 10 drops


For Dogs up to 25 lb:

Directions for use

  • Dogs up to 10 lb: 1 tablet per day
  • Dogs 11 - 25 lb: 2 tablets per day

For Dogs over 25 lb:

Directions for use:

  • Dogs 26 - 40 lb: 1 tablet per day
  • Dogs 41 - 75 lb: 2 tablets per day
  • Dogs over 75 lb: 3 tablets per day

Use initially for at least one month. Store product at room temperature. Do not expose to excessive heat or moisture.

These are Frequently Asked Questions:

Q. Can this be administered alongside prescription medications such as Vetoryl?
A. The product should not interfere with any medications currently being administered. It is up to the customer if they would like to administer our product alongside other medications. Always speak to a vet about how to take your pet off prescription medications safely.

Q. How long does the bottle last?
A. A bottle will last at least one month. A bottle may last 2 months for smaller pets.

Q. Are there any side effects?
A. In most cases there are no serious side effects associated with this product. Always cross-check the ingredients with any pre-existing allergy your pet may have.

Q. How long before I see results?
A. You should see results within 3-4 weeks. If you are not satisfied we recommend taking advantage of our guarantee.


Q. What is your return policy?
A. We offer a 100% money-back guarantee for up to 365 days. If it's not helping send it back for a full product refund.

*These statements below have not been evaluated by Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. The information on this Web site or in emails is designed for educational purposes only. It is not intended to be a substitute for informed medical advice or care. Prana Pets bases these statements on the historically established and widely acknowledged traditional uses of natural ingredients.